EPISODE 130 | RELEASED September 20, 2021

Tagamet and Benadryl for Dogs | Nancy Reese, DVM, MPVM, PhD Deep Dive

Do the over-the-counter medications Tagamet and Benadryl cure cancer in dogs, or just reduce its symptoms? Dr. Nancy Reese explains how these drugs work, and the role they can play in helping your dog fight cancer.


We’ve been helping folks fight dog cancer since 2008, and over the years we’ve seen dozens of fads come and go. There’s always a new “cure” being touted. The ones that actually DO help tend to stick around.

So here we are in 2021, and the latest internet sensational promise we see is a “protocol” that uses Benadryl and Tagamet to “cure” dog cancers. All dog cancers, is the story.

Is that a true story, or a hopeful wish?

Dr. Nancy Reese, our chief medical editor and resident epidemiologist/veterinarian, turns her big brain to the topic to help us understand why people hope these over-the-counter drugs can help their dogs … and how they actually can support our efforts.

Diphenhydramine (brand name Benadryl) and cimetidine (brand name Tagamet) are both antihistamines that work to block histamine receptors on cells. They have their place, in certain cancers. Listen in to find out the why and the how.

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